Substance
ID:736863
Names and Identifiers
Synonyms
3-羟基丙腈3-HydroxypropionitrileEthylene cyanohydrin2-Cyanoethanol
IUPAC name
3-hydroxypropanenitrile
IUPAC Traditional name
ethylene cyanohydrin
Registration numbers
CAS Number
EC Number
Beilstein Number
MDL Number
Merck Index
Properties
Product Information
Purity
98%
Safety Information
European Hazard Symbols
Irritant (Xi)GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
GHS Hazard statements
H315-H319-H335
Risk Statements
36/37/38
Safety Statements
26-37
TSCA Listed
是
RTECS
MU5250000
GHS Precautionary statements
P261-P305+P351+P338-P302+P352-P321-P405-P501A
Physical Property
Flash Point
128°C(262°F)
Density
1.041
Refractive Index
1.4250
Boiling Point
227-228°C
Melting Point
-46°C
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Protection of carboxylic acids as 2-cyanoethyl esters can be accomplished by DCC-DMAP coupling. The esters can be cleaved with TBAF in DMF-THF: Chem. Pharm. Bull., 42, 147 (1994), or Na2S in methanol: Chem. Pharm. Bull., 42, 1579 (1994).
• Precursor of 2-cyanoethyl 2,2,2-trichloroethyl phosphorochloridate, a reagent for the phosphorylation of nucleosides: Synthesis, 831 (1980); see 2,2,2-Trichloroethanol, L08163.
• Can also be used to protect the phosphate group, by condensation with 2,4,6-Triisopropylbenzenesulfonyl chloride, A11458: Chem. Pharm. Bull.,25, 2844 (1977), or DCC: J. Am. Chem. Soc., 83, 159 (1961). Cleavage can be effected with an amine: Tetrahedron Lett., 23, 5119 (1982), ammonia: J. Org. Chem., 59, 2482 (1994); Tetrahedron Lett., 35, 4311 (1994), or TBAF: Tetrahedron Lett., 1255 (1976).