Substance
ID:73654
Names and Identifiers
IUPAC Traditional name
propylthiouracil
IUPAC name
6-propyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-4-one
Synonyms
Propylthiouracil6-n-Propylthiouracil
Registration numbers
CAS Number
Properties
Safety Information
Storage Condition
-20°C
Product Information
Salt Data
Free Base
Molecule Details
Research Area: Endocrinology ,
Biological Activity:
Propylthiouracil is a thyroperoxidase and 5’-deiodinase inhibitor. It is a thioamide drug used to treat hyperthyroidism (including Graves’ disease) by decreasing the amount of thyroid hormone produced by the thyroid gland. It normally acts in thyroid hormone synthesis by oxidizing the anion iodide (I-) to iodine (I0), facilitating iodine’s addition to tyrosine residues on the hormone precursor thyroglobulin. It also acts by inhibiting the enzyme 5’-deiodinase (tetraiodothyronine 5’ deiodinase), which converts T4 to the active form T3. [1]
Biological Activity:
Propylthiouracil is a thyroperoxidase and 5’-deiodinase inhibitor. It is a thioamide drug used to treat hyperthyroidism (including Graves’ disease) by decreasing the amount of thyroid hormone produced by the thyroid gland. It normally acts in thyroid hormone synthesis by oxidizing the anion iodide (I-) to iodine (I0), facilitating iodine’s addition to tyrosine residues on the hormone precursor thyroglobulin. It also acts by inhibiting the enzyme 5’-deiodinase (tetraiodothyronine 5’ deiodinase), which converts T4 to the active form T3. [1]
Molecular Spectra
No Data Available
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References
• http://en.wikipedia.org/wiki/Propylthiouracil