Substance
ID:73620
Names and Identifiers
IUPAC name
(2S)-3-methyl-2-[N-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)pentanamido]butanoic acid
Synonyms
DiovanValsartan
IUPAC Traditional name
valsartan
Registration numbers
CAS Number
Properties
Safety Information
Storage Condition
-20°C
Product Information
Salt Data
Free Base
Pharmacology Properties
Target
Angiotensin recep
Molecule Details
Research Area: Cardiovascular Disease
Biological Activity:
Valsartan (Diovan) is an angiotensin II receptor antagonist with IC50 of ranging from 39.5 to116 µM. By blocking the action of angiotensin, valsartan dilates blood vessels and reduces blood pressure. In the Value trial, the angiotensin II receptor blocker valsartan produced a statistically significant 19% (p=0.02) relative increase in the prespecified secondary end point of myocardial infarction (fatal and non-fatal) compared with amlodipine. The CHARM-alternative trial showed a significant +52% (p=0.025) increase in myocardial infarction with candesartan (versus placebo) despite a reduction in blood pressure. [1]
Biological Activity:
Valsartan (Diovan) is an angiotensin II receptor antagonist with IC50 of ranging from 39.5 to116 µM. By blocking the action of angiotensin, valsartan dilates blood vessels and reduces blood pressure. In the Value trial, the angiotensin II receptor blocker valsartan produced a statistically significant 19% (p=0.02) relative increase in the prespecified secondary end point of myocardial infarction (fatal and non-fatal) compared with amlodipine. The CHARM-alternative trial showed a significant +52% (p=0.025) increase in myocardial infarction with candesartan (versus placebo) despite a reduction in blood pressure. [1]
Molecular Spectra
No Data Available
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References
• http://en.wikipedia.org/wiki/Valsartan