Substance
ID:73516
Names and Identifiers
IUPAC name
(3R)-3-[(3-hydroxy-2-phenylpropanoyl)oxy]-8-methyl-8-(propan-2-yl)-8-azabicyclo[3.2.1]octan-8-ium bromide
Synonyms
AeroventApoventIpratropium bromideAtrovent
IUPAC Traditional name
(3R)-3-[(3-hydroxy-2-phenylpropanoyl)oxy]-8-isopropyl-8-methyl-8-azabicyclo[3.2.1]octan-8-ium bromide
Registration numbers
CAS Number
Properties
Product Information
Salt Data
Bromide
Safety Information
Storage Condition
-20°C
Molecule Details
Research Area: Neurological Disease
Biological Activity:
Ipratropium bromide is a muscarinic antagonist, bronchodilator, N-Isopropyl salt of atropine. In anaesthetised guinea-pigs, bronchoconstriction induced by vagal nerve stimulation was potentiated by low doses of the antimuscarinic bronchodilator drug, ipratropium (0.01-1.0 µg/kg); the maximum effect was obtained with 1.0 µg/kg which doubled the bronchoconstriction. When the dose was increased above 1.0 µg/kg potentiation no longer occurred; instead the vagally induced bronchoconstriction was antagonised. [1]
Biological Activity:
Ipratropium bromide is a muscarinic antagonist, bronchodilator, N-Isopropyl salt of atropine. In anaesthetised guinea-pigs, bronchoconstriction induced by vagal nerve stimulation was potentiated by low doses of the antimuscarinic bronchodilator drug, ipratropium (0.01-1.0 µg/kg); the maximum effect was obtained with 1.0 µg/kg which doubled the bronchoconstriction. When the dose was increased above 1.0 µg/kg potentiation no longer occurred; instead the vagally induced bronchoconstriction was antagonised. [1]
Molecular Spectra
No Data Available
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References
• http://www.ncbi.nlm.nih.gov/pubmed/2958300