Substance
ID:73453
Names and Identifiers
IUPAC Traditional name
furosemide
IUPAC name
4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid
Synonyms
FrusemideFurosemide(Lasix)Lasix
Registration numbers
CAS Number
Properties
Safety Information
Storage Condition
-20°C
Product Information
Salt Data
Free Base
Pharmacology Properties
Target
Metabolic Disease
Molecule Details
Research Area: Cardiovascular Disease
Biological Activity:
Furosemide(Lasix) is a loop diuretic used in the treatment of congestive heart failure and edema. Furosemide acts by inhibiting the Na-K-2Cl symporter in the thick ascending limb of the loop of Henle. The action on the distal tubules is independent of any inhibitory effect on carbonic anhydrase or aldosterone; it also abolishes the corticomedullary osmotic gradient and blocks negative as well as positive free water clearance. [1]
Biological Activity:
Furosemide(Lasix) is a loop diuretic used in the treatment of congestive heart failure and edema. Furosemide acts by inhibiting the Na-K-2Cl symporter in the thick ascending limb of the loop of Henle. The action on the distal tubules is independent of any inhibitory effect on carbonic anhydrase or aldosterone; it also abolishes the corticomedullary osmotic gradient and blocks negative as well as positive free water clearance. [1]
Molecular Spectra
No Data Available
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References
• http://en.wikipedia.org/wiki/Furosemide