Substance
ID:73446
Names and Identifiers
IUPAC name
1-(4,4-diphenylbut-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride
IUPAC Traditional name
1-(4,4-diphenylbut-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride
Synonyms
SKF 89976A hydrochloride
Registration numbers
CAS Number
Properties
Product Information
Salt Data
hydrochloride
Safety Information
Storage Condition
-20°C
Pharmacology Properties
Target
Angiotensin receptor
Molecule Details
Research Area: Neurological Disease
Biological Activity:
SKF 89976A is a GABA transporter type 1 inhibitor with IC50 of 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively. It is selective for GAT-1. It inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM). Able to pass the blood-brain barrier after systemic administration and is active in vivo. [1]References on SKF 89976A HCl[1] Acta Physiol Scand. , 152(2):173-9, 1994 Oct.
Biological Activity:
SKF 89976A is a GABA transporter type 1 inhibitor with IC50 of 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively. It is selective for GAT-1. It inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM). Able to pass the blood-brain barrier after systemic administration and is active in vivo. [1]References on SKF 89976A HCl[1] Acta Physiol Scand. , 152(2):173-9, 1994 Oct.
Molecular Spectra
No Data Available
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References
• Lewin L et al. Acta Physiol Scand. 1994 Oct;152(2)