Substance
ID:73437
Names and Identifiers
IUPAC name
5-(1,4-diazepane-1-sulfonyl)isoquinoline hydrochloride
Synonyms
Fasudil HClHA-1077
IUPAC Traditional name
fasudil hydrochloride
Registration numbers
CAS Number
Properties
Product Information
Salt Data
hydrochloride
Safety Information
Storage Condition
-20°C
Pharmacology Properties
Target
ROCK
Molecule Details
Research Area: Cancer
Biological Activity:
Fasudil HCl is cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor with an IC50 of 10.7 μM. It is also a Ca2+ antagonist and vasodilator. It also inhibits proliferation of vascular smooth muscle cells. [1]References on Fasudil HCl (HA-1077)[1] Acta Neurochir Suppl., 2001, 77:201-4.
Biological Activity:
Fasudil HCl is cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor with an IC50 of 10.7 μM. It is also a Ca2+ antagonist and vasodilator. It also inhibits proliferation of vascular smooth muscle cells. [1]References on Fasudil HCl (HA-1077)[1] Acta Neurochir Suppl., 2001, 77:201-4.
Molecular Spectra
No Data Available
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References
• Shibuya M et al. Acta Neurochir Suppl. 2001;77:201