Substance
ID:73416
Names and Identifiers
Synonyms
AdenuricUloricFebuxostatTMX-67
IUPAC Traditional name
febuxostat
IUPAC name
2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid
Registration numbers
CAS Number
Properties
Product Information
Salt Data
Free Base
Safety Information
Storage Condition
-20°C
Pharmacology Properties
Target
XAO
Molecule Details
Research Area: Metabolic Disease
Biological Activity:
Febuxostat (Uloric) is a non-purine selective XAO inhibitor with IC50 of 114 -210 nM.It works by non-competitively blocking the channel leading to the active site on xanthine oxidase. [1] Xanthine oxidase is needed to successively oxidize both hypoxanthine and xanthine to uric acid. Hence, febuxostat inhibits xanthine oxidase, therefore reducing production of uric acid. [2][3]
Biological Activity:
Febuxostat (Uloric) is a non-purine selective XAO inhibitor with IC50 of 114 -210 nM.It works by non-competitively blocking the channel leading to the active site on xanthine oxidase. [1] Xanthine oxidase is needed to successively oxidize both hypoxanthine and xanthine to uric acid. Hence, febuxostat inhibits xanthine oxidase, therefore reducing production of uric acid. [2][3]
Molecular Spectra
No Data Available
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References
• Gaffo AL et al. Core Evid. 2010 Jun 15;4:25-36