Substance
ID:73392
Names and Identifiers
Synonyms
Tadalafil(Cialis)ICOS 351GF 196960IC 351Cialis
IUPAC Traditional name
tadalafil
IUPAC name
(2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11,13,15-tetraene-4,7-dione
Registration numbers
CAS Number
Properties
Product Information
Salt Data
Free Base
Pharmacology Properties
Target
PDE
Safety Information
Storage Condition
-20°C
Molecule Details
Research Area: Metabolic Disease
Biological Activity:
Tadalafil (Cialis) is a PDE inhibitor. Tadalafil(Cialis), which has demonstrated a high level of selectivity for PDE5 over the other phosphodiesterases, has shown efficacy in improving erectile function and sexual satisfaction in phase III trials. [1]PDE11A3, PDE11A2, and PDE11A1, which contain progressively shorter N-termini, were more sensitive than PDE11A4 to inhibition by Tadalafil(Cialis). [2]
Biological Activity:
Tadalafil (Cialis) is a PDE inhibitor. Tadalafil(Cialis), which has demonstrated a high level of selectivity for PDE5 over the other phosphodiesterases, has shown efficacy in improving erectile function and sexual satisfaction in phase III trials. [1]PDE11A3, PDE11A2, and PDE11A1, which contain progressively shorter N-termini, were more sensitive than PDE11A4 to inhibition by Tadalafil(Cialis). [2]
Molecular Spectra
No Data Available
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References
• Pomerol et al. Drugs Today. 2003; 39(2): 103