Substance
ID:73336
Names and Identifiers
IUPAC Traditional name
topiramate
Synonyms
TopiramateTopamax
IUPAC name
[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl sulfamate
Registration numbers
CAS Number
Properties
Product Information
Salt Data
Free Base
Safety Information
Storage Condition
-20°C
Pharmacology Properties
Target
carbonic anhydrase(CA)
Molecule Details
Research Area: Post-traumatic stress disorder, Alcoholism
Biological Activity:
Topiramate is an anticonvulsant drug. The exact mechanism of action is unknown, but four properties that may contribute to topiramate’s antiepileptic and antimigraine efficacy include a blockage of voltage-dependent sodium channels, an augmentation of gamma- aminobutyrate acid activity at some subtypes of the GABA- A receptors, antagonism of AMPA/kainate subtype of the glutamate receptor, and inhibition of the carbonic anhydrase enzyme, particularly isozymes II and IV . [1]
Biological Activity:
Topiramate is an anticonvulsant drug. The exact mechanism of action is unknown, but four properties that may contribute to topiramate’s antiepileptic and antimigraine efficacy include a blockage of voltage-dependent sodium channels, an augmentation of gamma- aminobutyrate acid activity at some subtypes of the GABA- A receptors, antagonism of AMPA/kainate subtype of the glutamate receptor, and inhibition of the carbonic anhydrase enzyme, particularly isozymes II and IV . [1]
Molecular Spectra
No Data Available
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References
• http://en.wikipedia.org/wiki/Topiramate