Substance
ID:73275
Names and Identifiers
Synonyms
LoratadineAlavertClaritin
IUPAC Traditional name
loratadine
IUPAC name
ethyl 4-{13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene}piperidine-1-carboxylate
Registration numbers
CAS Number
Properties
Product Information
Salt Data
Free Base
Pharmacology Properties
Target
Histamine receptors
Safety Information
Storage Condition
-20°C
Molecule Details
Research Area: Inflammation
Biological Activity:
Loratadine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. [1] Histamine is responsible for many features of allergic reactions. Loratadine (Alavert, Claritin) is a second-generation antihistamine agent closely structurally related to tricyclic antidepressants such as imipramine, and distantly related to the atypical antipsychotic quetiapine, used to treat allergies. [2]
Biological Activity:
Loratadine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. [1] Histamine is responsible for many features of allergic reactions. Loratadine (Alavert, Claritin) is a second-generation antihistamine agent closely structurally related to tricyclic antidepressants such as imipramine, and distantly related to the atypical antipsychotic quetiapine, used to treat allergies. [2]
Molecular Spectra
No Data Available
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References
• http://www.rxlist.com/claritin-drug.htm