Substance
ID:73199
Names and Identifiers
Synonyms
ValdoxanMelitorThymanaxAgomelatine
IUPAC name
N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide
IUPAC Traditional name
agomelatine
Registration numbers
CAS Number
Properties
Pharmacology Properties
Target
5-HT receptor
Product Information
Salt Data
Free Base
Safety Information
Storage Condition
-20°C
Molecule Details
Research Area: Depressive disorders
Biological Activity:
Agomelatine is an antidepressant drug. It is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. Activation of 5-HT2C receptors by serotonin inhibits dopamine and norepinephrine release. Antagonism of 5-HT2C results in an enhancement of DA and NE release and activity of frontocortical dopaminergic and adrenergic pathways. [1]Agomelatine is also a potent agonist at melatonin receptors which makes it the first melatonergic antidepressant. [2]References on Agomelatine[1] http://en.wikipedia.org/wiki/Agomelatine, , [2] Research Journal of Pharmaceutical, Biological and Chemical Sciences, ,
Biological Activity:
Agomelatine is an antidepressant drug. It is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. Activation of 5-HT2C receptors by serotonin inhibits dopamine and norepinephrine release. Antagonism of 5-HT2C results in an enhancement of DA and NE release and activity of frontocortical dopaminergic and adrenergic pathways. [1]Agomelatine is also a potent agonist at melatonin receptors which makes it the first melatonergic antidepressant. [2]References on Agomelatine[1] http://en.wikipedia.org/wiki/Agomelatine, , [2] Research Journal of Pharmaceutical, Biological and Chemical Sciences, ,
Molecular Spectra
No Data Available
Click here to submit data
References
• http://en.wikipedia.org/wiki/Agomelatine