Substance
ID:73181
Names and Identifiers
IUPAC Traditional name
clofarabine
IUPAC name
(2R,3R,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
Synonyms
ClofarabineClolarEvoltra
Registration numbers
CAS Number
Properties
Product Information
Salt Data
Free Base
Pharmacology Properties
Target
DNA/RNA synthesis
Physical Property
Solubility
DMSO
Safety Information
Storage Condition
-20°C
Molecule Details
Research Area: Non-Hodgkin's lymphoma,B-cell lymphoma
Biological Activity:
Clofarabine is a second generation purine nucleoside analog with antineoplastic activity. It is phosphorylated intracellularly, which inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA. This nucleoside analog also disrupts mitochondrial function and membrane integrity, resulting in the release of pre-apoptotic factors, including cytochrome C and apoptotic-inducing factor, which activate apoptosis. [1]It is used for treating relapsed or refractory acute lymphoblastic leukaemia (ALL) in children, after at least two other types of treatment have failed. [2]
Biological Activity:
Clofarabine is a second generation purine nucleoside analog with antineoplastic activity. It is phosphorylated intracellularly, which inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA. This nucleoside analog also disrupts mitochondrial function and membrane integrity, resulting in the release of pre-apoptotic factors, including cytochrome C and apoptotic-inducing factor, which activate apoptosis. [1]It is used for treating relapsed or refractory acute lymphoblastic leukaemia (ALL) in children, after at least two other types of treatment have failed. [2]
Molecular Spectra
No Data Available
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References
• http://en.wikipedia.org/wiki/Clofarabine