Substance
ID:73180
Names and Identifiers
IUPAC name
2-[bis(2-chloroethyl)amino]-1,3,2$l^{5}-oxazaphosphinan-2-one
Synonyms
Clafen(Cyclophosphamide)CytoxancyclophosphamideEndoxanNeosar
IUPAC Traditional name
cyclophosphamide
Registration numbers
CAS Number
Properties
Product Information
Salt Data
Free Base
Pharmacology Properties
Target
DNA/RNA synthesis
Safety Information
Storage Condition
-20°C
Molecule Details
Research Area: Cancer
Biological Activity:
Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death. [1]Cyclophosphamide is given as a treatment for many types of cancer, among them lymphomas, ovary, breast, and bladder; and chronic lymphocytic leukaemia. [2]This agent inhibited cell proliferation of NCI-H727 with IC50 at 9.3 nM. [3]
Biological Activity:
Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death. [1]Cyclophosphamide is given as a treatment for many types of cancer, among them lymphomas, ovary, breast, and bladder; and chronic lymphocytic leukaemia. [2]This agent inhibited cell proliferation of NCI-H727 with IC50 at 9.3 nM. [3]
Molecular Spectra
No Data Available
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References
• http://en.wikipedia.org/wiki/Cyclophosphamide