Substance
ID:73174
Names and Identifiers
Synonyms
TrexallMethotrexateRheumatrexAbitrexate(Methotrexate)
IUPAC Traditional name
methotrexate
IUPAC name
(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid
Registration numbers
CAS Number
Properties
Product Information
Salt Data
Free Base
Safety Information
Storage Condition
-20°C
Pharmacology Properties
Target
Antimetabolite
Molecule Details
Research Area: Immunology
Biological Activity:
Abitrexate(Methotrexate) is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate competitively and irreversibly inhibits dihydrofolate reductase (DHFR), resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear. [1,2] In a panel of six pediatric leukemia and lymphoma cell lines, this drug performed growth inhibitory activity with median IC50 78 nM. [3]
Biological Activity:
Abitrexate(Methotrexate) is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate competitively and irreversibly inhibits dihydrofolate reductase (DHFR), resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear. [1,2] In a panel of six pediatric leukemia and lymphoma cell lines, this drug performed growth inhibitory activity with median IC50 78 nM. [3]
Molecular Spectra
No Data Available
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References
• http://en.wikipedia.org/wiki/Methotrexate