Substance
ID:73155
Names and Identifiers
IUPAC Traditional name
anastrozole
IUPAC name
2-[3-(1-cyano-1-methylethyl)-5-(1H-1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile
Synonyms
Anastrozole(Arimidex)AstraZenecaArimidex
Registration numbers
CAS Number
Properties
Safety Information
Storage Condition
-20°C
Physical Property
Solubility
DMSO
Product Information
Salt Data
Free Base
Pharmacology Properties
Target
Aromatase
Molecule Details
Research Area: Endocrinology
Biological Activity:
Anastrozole inhibits the enzyme aromatase, which is responsible for converting androgens to estrogens. Anastrozole binds reversibly to the aromatase enzyme through competitive inhibition.[1] Elevated levels of estrogens may increase the severity of breast cancer, as sex hormones can cause hyperplasia and differentiation at estrogen receptor sites.[1] Anastrozole is used to treat breast cancer after surgery and for metastases in post-menopausal women.[1]
Biological Activity:
Anastrozole inhibits the enzyme aromatase, which is responsible for converting androgens to estrogens. Anastrozole binds reversibly to the aromatase enzyme through competitive inhibition.[1] Elevated levels of estrogens may increase the severity of breast cancer, as sex hormones can cause hyperplasia and differentiation at estrogen receptor sites.[1] Anastrozole is used to treat breast cancer after surgery and for metastases in post-menopausal women.[1]
Molecular Spectra
No Data Available
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References
• http://en.wikipedia.org/wiki/Anastrozole