Substance
ID:73151
Names and Identifiers
IUPAC name
1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[(2S)-3-methyl-2-{[methyl({[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl})carbamoyl]amino}butanamido]-1,6-diphenylhexan-2-yl]carbamate
Synonyms
NorvirRitonavirNorvir Softgel
IUPAC Traditional name
ritonavir
Registration numbers
CAS Number
Properties
Product Information
Salt Data
Free Base
Safety Information
Storage Condition
-20°C
Pharmacology Properties
Target
HIV protease
Molecule Details
Research Area: Immunology
Biological Activity:
Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS. It is now rarely used for its own antiviral activity, but remains widely used as a booster of other protease inhibitors. More specifically, ritonavir is used to inhibit a particular liver enzyme that normally metabolizes protease inhibitors, cytochrome P450-3A4 (CYP3A4). The drug’s molecular structure inhibits CYP3A4, so a low dose can be used to enhance other protease inhibitors. This discovery has drastically reduced the adverse effects and improved the efficacy of PI’s and HAART. [1]
Biological Activity:
Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS. It is now rarely used for its own antiviral activity, but remains widely used as a booster of other protease inhibitors. More specifically, ritonavir is used to inhibit a particular liver enzyme that normally metabolizes protease inhibitors, cytochrome P450-3A4 (CYP3A4). The drug’s molecular structure inhibits CYP3A4, so a low dose can be used to enhance other protease inhibitors. This discovery has drastically reduced the adverse effects and improved the efficacy of PI’s and HAART. [1]
Molecular Spectra
No Data Available
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References
• http://en.wikipedia.org/wiki/Ritonavir