Substance
ID:723203
Names and Identifiers
IUPAC Traditional name
1-butyne, 3-chloro-3-methyl-
IUPAC name
3-chloro-3-methylbut-1-yne
Synonyms
3-Chloro-3-methyl-1-butyne3-氯-3-甲基-1-丁炔1,1-Dimethylpropargyl chloride
Properties
Safety Information
GHS Precautionary statements
P210-P241-P303+P361+P353-P305+P351+P338-P405-P501A
GHS Hazard statements
H225-H315-H319-H335
Hazard Class
3
Packing Group
II
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Flammable gases, category 1
Flammable aerosols, categories 1,2
Flammable liquids, categories 1,2,3
Self-reactive substances and mixtures, Types B,C,D,E,F
Pyrophoric liquids, category 1
Pyrophoric solids, category 1
Self-heating substances and mixtures
Substances and mixtures, which in contact with water, emit flammable gases, categories 1,2,3
Organic peroxides, Types B,C,D,E,F
European Hazard Symbols
Irritant (Xi)
Flammable (F)Safety Statements
16-26-29-33-37
UN Number
UN1993
TSCA Listed
是
Risk Statements
11-36/37/38
Physical Property
Density
0.913
Melting Point
-61°C
Boiling Point
73-75°C
Refractive Index
1.4178
Flash Point
4°C(40°F)
Product Information
Purity
95%
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Reagent for an improved 2-step introduction of the 1,1-dimethylallyl (DMA) ester protecting group for carboxylic acids. Reaction with the acid in the presence of copper(I) iodide and cesium carbonate in DMF affords the 1,1-dimethylpropargyl ester. Hydrogenation with Pd/barium sulfate/quinoline affords the 1,1-dimethylallyl ester. The DMA group is resistant to nucleophilic attack, but readily cleaved under non-acidic conditions with Pd(0), which is an advantage compared with the tert-butyl ester in solid-phase peptide synthesis: Org. Lett., 7, 1473 (2005).