Substance
ID:722698
Names and Identifiers
IUPAC Traditional name
2-chloro-4,6-dimethoxy-1,3,5-triazine
IUPAC name
2-chloro-4,6-dimethoxy-1,3,5-triazine
Synonyms
2-Chloro-4,6-dimethoxy-1,3,5-triazine2-氯-4,6-二甲氧基-1,3,5-三嗪
Registration numbers
MDL Number
Beilstein Number
EC Number
CAS Number
Properties
Physical Property
Melting Point
75-79°C
Boiling Point
99-100°C/1mm
Safety Information
Risk Statements
36/37/38
Safety Statements
26-37-60
TSCA Listed
否
GHS Precautionary statements
P261-P305+P351+P338-P302+P352-P321-P405-P501A
GHS Hazard statements
H315-H319-H335
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
European Hazard Symbols
Irritant (Xi)Product Information
Purity
98%
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Similarly, carboxylic acids are converted to Weinreb amides by reaction with N,O-dialkyl hydroxylamines: J. Org. Chem., 66, 2534 (2001).
• Reagent for activation of carboxylic acids to nucleophiles: J. Org. Chem., 63, 4248 (1998). Peptide coupling reagent: Synthesis, 917 (1987). With N-methylmorpholine forms the quaternary chloride (DMTMM) which is a valuable low-cost coupling agent in solid-phase peptide synthesis: Synlett, 275 (2000). For a reexamination of the use of the reagent in peptide coupling, see: Tetrahedron Lett., 42, 4161 (2002); see also Appendix 6.
• Can also be used for the esterification of carboxylic acids: Synthesis, 593 (1999). The intermediate active esters can be hydrogenolyzed, providing a simple method for reduction of acids to aldehydes; at higher pressures, further reduction to the alcohol can be effected: J. Org. Chem., 64, 8962 (1999).