Substance
ID:720785
Names and Identifiers
IUPAC name
2-(hydroxymethyl)-2,3-dihydro-1H-isoindole-1,3-dione
IUPAC Traditional name
N-(hydroxymethyl)phthalimide
Synonyms
N-(Hydroxymethyl)phthalimideN-(羟甲基)邻苯二甲酰亚胺
Registration numbers
Beilstein Number
EC Number
MDL Number
CAS Number
Properties
Physical Property
Melting Point
140-147°C
Safety Information
GHS Hazard statements
H315-H319-H335
Risk Statements
36/37/38
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Safety Statements
26-37
RTECS
TI5270000
TSCA Listed
是
European Hazard Symbols
Irritant (Xi)GHS Precautionary statements
P261-P305+P351+P338-P302+P352-P321-P405-P501A
Product Information
Purity
97%
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• In the presence of diethylamine, protection of carboxylic acids as phthalimidomethyl esters has been reported. The group can be cleaved with hydrazine in MeOH, by a variety of basic or acidic conditions: Rec. Trav. Chim., 82, 941 (1963), or with Zn in AcOH: Chem. Ind. (London), 1204 (1970).
• Used for the introduction of the phthalimidomethyl group by electrophilic substitution of aromatic compounds. For reviews on this amidomethylation reaction, see: Org. React., 14, 52 (1965); Synthesis, 49, (1970); 85, 181 (1984).