Substance
ID:718222
Names and Identifiers
IUPAC name
(1H-1,2,3-benzotriazol-1-yloxy)tris(dimethylamino)phosphanium; hexafluoro-λ5-phosphanuide
Synonyms
Castro's reagentBOP Reagent1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate1H-苯并三唑-1-基氧代三(二甲氨基)磷鎓 六氟磷酸盐
IUPAC Traditional name
(1,2,3-benzotriazol-1-yloxy)tris(dimethylamino)phosphanium hexafluorophosphate
Registration numbers
CAS Number
MDL Number
EC Number
Beilstein Number
Properties
Safety Information
European Hazard Symbols
Irritant (Xi)
Flammable (F)GHS Precautionary statements
P210-P241-P305+P351+P338-P302+P352-P405-P501A
Storage Warning
Moisture & Light Sensitive
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Flammable gases, category 1
Flammable aerosols, categories 1,2
Flammable liquids, categories 1,2,3
Self-reactive substances and mixtures, Types B,C,D,E,F
Pyrophoric liquids, category 1
Pyrophoric solids, category 1
Self-heating substances and mixtures
Substances and mixtures, which in contact with water, emit flammable gases, categories 1,2,3
Organic peroxides, Types B,C,D,E,F
Safety Statements
26-37-60
TSCA Listed
否
GHS Hazard statements
H228-H315-H319-H335
Packing Group
II
Hazard Class
4.1
UN Number
UN1325
Risk Statements
11-36/37/38-44
Product Information
Purity
98%
Physical Property
Melting Point
ca 138°C dec.
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Reagent for high yield, low racemization peptide coupling: Tetrahedron Lett., 1219 (1975). See Appendix 6.
• The carboxyphosphonium salts formed by reaction with carboxylic acids can be reduced with NaBH4, providng a mild method for reduction of acids to alcohols: Tetrahedron lett., 39, 3319 (1998).
• Mild and efficient reagent for the preparation of esters from carboxylic acids and alcohols: Tetrahedron Lett., 36, 4253 (1995); for esterification of amino acids at low temperatures, see: Tetrahedron Lett., 35, 5603 (1994); for use in formation of mixed phosphonate diesters, see: J. Org. Chem., 60, 5214 (1995).
• Promotes the reaction of aliphatic primary amines with CS2 to give isothiocyanates which can be isolated in high yield or reacted in situ with nucleophiles: J. Chem. Soc., Chem. Commun., 1995 (1995).