Substance
ID:716690
Names and Identifiers
IUPAC Traditional name
2-bromoacetonitrile
IUPAC name
2-bromoacetonitrile
Synonyms
溴乙腈Bromoacetonitrile
Registration numbers
MDL Number
EC Number
Beilstein Number
CAS Number
Properties
Safety Information
Risk Statements
23/24/25-34
Safety Statements
26-27-36/37/39-45
Hazard Class
8
UN Number
UN2922
RTECS
AL7970000
GHS Hazard statements
H300-H310-H330-H314-H318-H227
Packing Group
II
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
Corrosive to metals, category 1
Skin corrosion, categories 1A,1B,1C
Serious eye damage, category 1
European Hazard Symbols
Toxic (T)TSCA Listed
否
GHS Precautionary statements
P210-P301+P310-P303+P361+P353-P304+P340-P305+P351+P338-P320-P330-P361-P405-P501A
Product Information
Purity
96%
Physical Property
Flash Point
81°C(178°F)
Refractive Index
1.4800
Boiling Point
150°C
Density
1.722
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• The Reformatsky-type reaction with cyclohexanone is more successful in the presence of a Zn/Ag couple than with the conventional Zn-Cu couple: Synth. Commun., 19, 2355 (1989). Good yields of ?-hydroxy nitriles have also been achieved from aldehydes and ketones using Zn and TMS chloride: Tetrahedron Lett., 31, 2205 (1990). The condensation with aldehydes can also be mediated by active Ni: Tetrahedron Lett., 26, 155 (1985). The reaction with aldehydes in the presence of Zn and tri-n-butylphosphine gives ɑ?-unsaturated nitriles directly: Synth. Commun., 20, 3277 (1990).
• Phenols can be protected (K2CO3, acetone) as their cyanomethyl ethers which can be cleaved by hydrogenation of the nitrile: Tetrahedron Lett., 34, 7567 (1993).