Substance
ID:716594
Names and Identifiers
IUPAC Traditional name
4-methoxybenzenesulfonyl chloride
IUPAC name
4-methoxybenzene-1-sulfonyl chloride
Synonyms
4-甲氧基苯磺酰氯4-Methoxybenzenesulfonyl chloridep-Anisolesulfonyl chloride
Properties
Physical Property
Flash Point
>110°C(230°F)
Boiling Point
119-122°C/0.4mm
Melting Point
37-42°C
Safety Information
Packing Group
II
Safety Statements
26-36/37/39-45
Storage Warning
Moisture Sensitive
GHS Hazard statements
H314-H318
Hazard Class
8
European Hazard Symbols
Corrosive (C)GHS Pictograms
Corrosive to metals, category 1
Skin corrosion, categories 1A,1B,1C
Serious eye damage, category 1
Risk Statements
34
GHS Precautionary statements
P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501A
TSCA Listed
否
UN Number
UN3261
Product Information
Purity
98+%
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Amines and other N-functions can be protected as 4-methoxybenzenesufonyl (PMBS, Mps) derivatives: Chem. Pharm. Bull., 29, 2592 (1981), useful for the imidazole in histidines, stable to TFA and HBr/AcOH: Bull. Chem. Soc. Jpn., 47, 3146 (1974); J. Org. Chem., 45, 547 (1980); deprotection in TFA is promoted by dimethyl sulfide: J. Chem. Soc., Chem. Commun., 955 (1979). For deprotection of PMBS-indoles using Mg in methanol, see: J. Org. Chem., 62, 6519 (1997).
• Also used for protection of the guanidino function of arginine residues in peptide synthesis. The sulfonamide is cleaved by triflic acid under less drastic conditions than tosyl groups: Chem. Pharm. Bull., 24, 1568 (1976). Compare also 4-Methoxy-2,3,6-trimethylbenzenesulfonyl chloride, L11829. See Appendix 6.