Substance
ID:716208
Names and Identifiers
IUPAC name
2-bromopyridine
IUPAC Traditional name
2-bromopyridine
Synonyms
2-Bromopyridine2-溴吡啶
Registration numbers
CAS Number
Beilstein Number
EC Number
MDL Number
Properties
Physical Property
Boiling Point
192-194°C
Flash Point
97°C(207°F)
Density
1.625
Refractive Index
1.5720
Safety Information
GHS Precautionary statements
P280H-P305+P351+P338-P309-P310
Hazard Class
6.1
GHS Hazard statements
H301-H310-H315-H319-H335
TSCA Listed
是
UN Number
UN2810
Packing Group
II
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
Risk Statements
24/25-36/37/38
RTECS
US3850000
Safety Statements
26-36/37-45
European Hazard Symbols
Toxic (T)Product Information
Purity
99%
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Bromopyridines can be converted to the Grignards by Mg exchange with i-PrMgCl: Tetrahdron Lett., 40, 4339 (1999).
• Reaction with n-BuLi gives 2-lithio-pyridine. Subsequent reaction at low temperatures with PCl3 gives, as the major product, 2,2'-bipyridine, along with a low yield of the expected tris(2-pyridyl)phosphine. POCl3 or SOCl2 also promote the symmetrical coupling reaction: Heteroatom. Chem., 5, 409 (1994). In contrast, reaction with LDA in THF at -78o results in lithiation at the 3-position, giving access to 3-substituted 2-bromopyridines: Synthesis, 235, 237 (1982). See also: Org. Lett., 3, 835 (2001).