Substance
ID:715726
Names and Identifiers
IUPAC Traditional name
1-methylimidazole
IUPAC name
1-methyl-1H-imidazole
Synonyms
1-Methylimidazole1-甲基咪唑
Registration numbers
EC Number
Beilstein Number
CAS Number
MDL Number
Properties
Safety Information
GHS Pictograms
Corrosive to metals, category 1
Skin corrosion, categories 1A,1B,1C
Serious eye damage, category 1
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
RTECS
NI7000000
GHS Precautionary statements
P210-P260-P303+P361+P353-P305+P351+P338-P405-P501A
Packing Group
III
Risk Statements
21/22-34
TSCA Listed
是
Hazard Class
8
European Hazard Symbols
Corrosive (C)
Harmful (X)GHS Hazard statements
H314-H302-H312-H227
UN Number
UN2922
Storage Warning
Hygroscopic
Safety Statements
1/2-26-36-45
Product Information
Purity
99%
Physical Property
Flash Point
92°C(197°F)
Density
1.031
Melting Point
-6°C
Boiling Point
195-197°C
Refractive Index
1.4970
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Undergoes lithiation at the 2-position. Reaction of the Li derivative with ketones followed by dehydration with acetic anhydride is a good route to 2-alkylideneimidazoles: Synthesis, 78 (1990). Likewise, reaction with benzonitrile gives the 2-benzoyl derivative, the carbonyl group of which undergoes Wittig methylenation: Synth. Commun., 20, 321 (1990).
• Reacts with acid chlorides, including chloroformates, to give N-acylimidazolium salts, which are useful reagents for the acylation of, for example, amino acids: Bull. Soc. Chim. Fr., 1021 (1973).
• Useful base for peptide coupling, etc. See, e.g.: J. Chem. Soc., Chem. Commun., 2223 (1995). For peptide reagents, see Appendix 6.