Substance
ID:715576
Names and Identifiers
IUPAC Traditional name
tert-butoxycarbohydrazide
IUPAC name
(tert-butoxy)carbohydrazide
Synonyms
肼基甲酸叔丁酯tert-Butyl carbazatetert-ButoxycarbonylhydrazineBoc-hydrazine
Registration numbers
CAS Number
MDL Number
EC Number
Beilstein Number
Properties
Safety Information
GHS Precautionary statements
P210-P241-P280-P240-P370+P378A
Packing Group
III
GHS Pictograms
Flammable gases, category 1
Flammable aerosols, categories 1,2
Flammable liquids, categories 1,2,3
Self-reactive substances and mixtures, Types B,C,D,E,F
Pyrophoric liquids, category 1
Pyrophoric solids, category 1
Self-heating substances and mixtures
Substances and mixtures, which in contact with water, emit flammable gases, categories 1,2,3
Organic peroxides, Types B,C,D,E,F
European Hazard Symbols
Flammable (F)GHS Hazard statements
H228
Safety Statements
33
TSCA Listed
是
Risk Statements
11
Hazard Class
4.1
Storage Warning
Moisture Sensitive
UN Number
UN1325
Physical Property
Melting Point
37-41°C
Boiling Point
63-65°C/0.1mm
Flash Point
91°C(195°F)
Product Information
Purity
98+%
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Protected hydrazine derivative, permitting selective reaction at one N atom, followed by mild acidic cleavage of the Boc group. For preparation of, e.g. N-aminosuccinimide, free from the cyclic hydrazide, see: J. Org. Chem., 37, 2040 (1972). Similarly, reaction with carbonyl or sulfonyl halides, followed by cleavage with HCl, provides a route to monoacyl hydrazides: Synthesis, 244 (1980). It is also commonly used in the synthesis of aza-amino acids; see, for example: Synthesis, 141 (1991) and references therein.
• Precursor of the somewhat unstable tert-butyl azidoformate, useful for introduction of the Boc protecting group, see: Org. Synth. Coll., 5, 157 (1973). Caution! Possible violent decomposition of this azide on heating.
• Monoalkylhydrazines can be prepared via reduction of Boc-hydrazones with borane-THF, and cleavage with HCl: J. Org. Chem., 46, 5413 (1981).