Substance
ID:715280
Names and Identifiers
IUPAC Traditional name
2-bromothiophene
IUPAC name
2-bromothiophene
Synonyms
2-Bromothiophene2-Thienyl bromide2-溴噻吩
Registration numbers
CAS Number
MDL Number
Beilstein Number
EC Number
Properties
Physical Property
Melting Point
<-10°C
Refractive Index
1.5860
Boiling Point
149-152°C
Density
1.701
Flash Point
58°C(136°F)
Product Information
Purity
98+%
Safety Information
Safety Statements
9-26-27-36/37/39-45-60
UN Number
UN2929
European Hazard Symbols
Toxic (T)GHS Precautionary statements
P210-P301+P310-P303+P361+P353-P304+P340-P305+P351+P338-P320-P330-P361-P405-P501A
TSCA Listed
是
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
Flammable gases, category 1
Flammable aerosols, categories 1,2
Flammable liquids, categories 1,2,3
Self-reactive substances and mixtures, Types B,C,D,E,F
Pyrophoric liquids, category 1
Pyrophoric solids, category 1
Self-heating substances and mixtures
Substances and mixtures, which in contact with water, emit flammable gases, categories 1,2,3
Organic peroxides, Types B,C,D,E,F
GHS Hazard statements
H300-H310-H330-H315-H319-H226
Storage Warning
Light Sensitive
Hazard Class
6.1
Packing Group
II
Risk Statements
23/24/25-36/38
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• The bromo-substituent can be readily displaced by methoxide in methanol in the presence of a Cu(I) catalyst: Synth. Commun., 20, 213 (1990). For coupling reaction with Thiophene-2-thiol, B22642, in the presence of Cu2O, to give 2,2'-dithienyl sulfide, see: Org. Synth. Coll., 6, 558 (1988).
• Allylic alcohols are thienylated by means of a Heck-type, Pd-catalyzed coupling reaction; the products are ketones formed by rearrangement: Chem. Lett., 423 (1977). Coupling with iodoarenes can be induced at the 5-position by the use of a palladium(II) catalyst in the presence of silver nitrate and potassium fluoride, providing access to 5-aryl-2-bromothiophene derivatives, which may be further elaborated by reaction with the available 2-bromo-substituent: Org. Lett., 7, 5083 (2005).