Substance
ID:715185
Names and Identifiers
IUPAC Traditional name
triphenylmethyl chloride
IUPAC name
(chlorodiphenylmethyl)benzene
Synonyms
Trityl chlorideTriphenylmethyl chloride三苯基氯甲烷Chlorotriphenylmethane
Properties
Product Information
Purity
98%
Physical Property
Boiling Point
230-235°C/20mm
Melting Point
110-114°C
Safety Information
GHS Hazard statements
H314-H318-H400-H410
TSCA Listed
是
Storage Warning
Moisture Sensitive
Packing Group
II
GHS Pictograms
Hazardous to the aquatic environment
Acute hazard, category1
Chronic hazard, categories 1,2
Corrosive to metals, category 1
Skin corrosion, categories 1A,1B,1C
Serious eye damage, category 1
European Hazard Symbols
Nature polluting (N)
Corrosive (C)Risk Statements
34-50/53
Hazard Class
8
GHS Precautionary statements
P280-P273-P305+P351+P338-P309-P310
UN Number
UN3261
RTECS
PA6450000
Safety Statements
26-36/37/39-45-60-61
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Progressively more acid-labile protecting groups contain one, two or three p-methoxy-groups: 4-Methoxytrityl chloride, A10545, 4,4'-Dimethoxytrityl chloride, A11626, and 4,4',4''-Trimethoxytrityl chloride, L00629, respectively.
• For a one-pot procedure for the high yield, racemization-free N-tritylation of amino acids, by means of prior in situ O-silylation, see: J. Org. Chem., 47, 1324 (1982). N-Trt- derivatives of amino acids have also been converted to Leuchs' anhydrides by treatment with phosgene or triphosgene, and the products coupled with amino acid esters to give dipeptides in good yields without racemization: J. Org. Chem., 64, 2532 (1999). See also 9-Bromo-9-phenylfluorene, L14225.
• Reagent for protection of N, S and particularly O functions as trityl (Trt) derivatives, stable to a wide range of conditions, but readily cleaved by mild acid.
• For an improved method for O-tritylation in triethylamine in the presence of catalytic amounts of DMAP, see: Tetrahedron Lett., 95 (1979).