Substance
ID:715132
Names and Identifiers
IUPAC name
methanesulfonylbenzene
IUPAC Traditional name
sulfone, phenyl, methyl-
Synonyms
甲基苯基砜Methyl phenyl sulfone
Registration numbers
CAS Number
EC Number
MDL Number
Beilstein Number
Properties
Product Information
Purity
98+%
Safety Information
GHS Hazard statements
H302
GHS Precautionary statements
P264-P270-P301+P312-P330-P501A
TSCA Listed
否
Risk Statements
22
RTECS
WR6800000
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
European Hazard Symbols
Harmful (X)Safety Statements
36
Physical Property
Melting Point
85-88°C
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Adds to aldehydes and ketones in the presence of base, e.g. n-BuLi, to give ?-hydroxy sulfones. Conversion of the OH to, e.g. to mesylate, and elimination/desulfurative reduction with sodium amalgam provides a 1-substitued or 1,1-disubstituted alkene by the Julia olefination reaction: Tetrahedron Lett., 4833 (1973); J. Chem. Soc., Perkin 1, 829 (1978). For reaction scheme, see Ethyl phenyl sulfone, A10710. The adducts with aldehydes can also be rearranged to give the dimethyl acetals of the homologous aldehydes: J. Chem. Soc., Perkin 1, 1646 (1978). Reaction with acyl halides gives ?-keto sulfones: J. Org. Chem., 53, 906 (1988).
• Factors governing the selective alkylation have been studied. Lithium bases favor dialkylation. For monoalkylation, a potassium base, e.g. KH in THF, should be used: J. Org. Chem., 55, 2234 (1990).