Substance
ID:715067
Names and Identifiers
IUPAC name
1-bromo-4-fluorobenzene
IUPAC Traditional name
P-bromofluorobenzene
Synonyms
1-溴-4-氟苯1-Bromo-4-fluorobenzene4-Bromofluorobenzene
Registration numbers
CAS Number
MDL Number
Beilstein Number
EC Number
Properties
Safety Information
European Hazard Symbols
Harmful (X)TSCA Listed
是
GHS Precautionary statements
P261-P305+P351+P338
Hazard Class
3
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Flammable gases, category 1
Flammable aerosols, categories 1,2
Flammable liquids, categories 1,2,3
Self-reactive substances and mixtures, Types B,C,D,E,F
Pyrophoric liquids, category 1
Pyrophoric solids, category 1
Self-heating substances and mixtures
Substances and mixtures, which in contact with water, emit flammable gases, categories 1,2,3
Organic peroxides, Types B,C,D,E,F
GHS Hazard statements
H226-H332-H319-H313
Risk Statements
10-20-36
Packing Group
III
RTECS
CY9033750
Safety Statements
26
UN Number
UN1993
Physical Property
Boiling Point
151-153°C
Density
1.604
Refractive Index
1.5270
Melting Point
-16°C
Flash Point
60°C(140°F)
Product Information
Purity
99%
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Lithiation with LDA at -75o results mainly in deprotonation ortho to F; subsequent reaction with CO2 gives 5-bromo-2-fluorobenzoic acid: Tetrahedron Lett., 33, 7495 (1992). Improved yields are obtained by the use of Li 2,2,6,6-tetramethylpiperidide (LTMP) as base: Tetrahedron Lett., 37, 6551 (1996).
• The Br undergoes selective displacement with Na alkoxides in NMP, in the presence of CuBr: Tetrahedron, 48, 3633 (1992).