Substance
ID:715064
Names and Identifiers
IUPAC name
1-[chloro(4-methoxyphenyl)benzyl]-4-methoxybenzene
IUPAC Traditional name
1-[chloro(4-methoxyphenyl)benzyl]-4-methoxybenzene
Synonyms
DMT4,4'-Dimethoxytriphenylmethyl chloride4,4'-Dimethoxytrityl chloride4,4'-二甲氧基三苯基氯甲烷
Registration numbers
CAS Number
Beilstein Number
EC Number
MDL Number
Properties
Safety Information
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
GHS Hazard statements
H315-H319-H335
Risk Statements
36/37/38
European Hazard Symbols
Irritant (Xi)GHS Precautionary statements
P261-P305+P351+P338-P302+P352-P321-P405-P501A
TSCA Listed
否
Safety Statements
26-37
Storage Warning
Moisture Sensitive
Product Information
Purity
98%
Physical Property
Melting Point
121-127°C
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• In a comparison with Mmt for N-protection during solid-phase peptide synthesis, the N-Mmt group was found to survive intact whereas N-Dmt derivatives decomposed slowly in protic solvents: Tetrahedron. Lett., 39, 1733 (1998).
• For selective protection and deprotection procedures for SH and OH groups in nucleoside derivatives, see: Synlett, 83 (1993).
• Selective cleavage in acid-sensitive nucleosides and nucleotides without competing N-glycosyl cleavage has also been accomplished by the use of 1,1,1,3,3,3-Hexafluoro-2-propanol, A12747: Tetrahedron Lett., 36, 7833 (1995). For deprotection with montmorillonite K 10 clay, see: J. Org. Chem., 61, 9026 (1996).
• Reagent for protection of alcohols, compare Chlorotriphenylmethane, A11799 as their dimethoxytrityl (Dmt) ethers. Mono-, di- and trimethoxytrityl chlorides form ethers of increasing acid-lability, each MeO group increasing the rate of cleavage by ca x10: J. Am. Chem. Soc., 84, 430 (1962); 85, 3821 (1963). The group is introduced e.g. by reaction with the alcohol in pyridine solution. For use of DMAP as catalyst, see: J. Am. Chem. Soc., 104, 1316 (1982), or of silver nitrate: Can. J. Chem., 60, 1106 (1982).