Substance
ID:715046
Names and Identifiers
IUPAC name
1-(benzenesulfonyl)-1H-pyrrole
IUPAC Traditional name
1-(benzenesulfonyl)pyrrole
Synonyms
1-(Phenylsulfonyl)pyrrole1-(Benzenesulfonyl)pyrrole1-(苯基磺酰基)吡咯
Properties
Safety Information
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Risk Statements
36/37/38
Safety Statements
26-37
TSCA Listed
否
European Hazard Symbols
Irritant (Xi)GHS Hazard statements
H315-H319-H335
GHS Precautionary statements
P261-P305+P351+P338-P302+P352-P321-P405-P501A
Product Information
Purity
98%
Physical Property
Melting Point
87-90°C
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Useful protected pyrrole derivative which undergoes regioselective electrophilic substitution, e.g. Friedel-Crafts acylation, at the 3-position: Tetrahedron Lett., 22, 4899, 4901 (1981); Synthesis, 353 (1985) (review); J. Org. Chem., 48, 3214 (1983). The phenylsulfonyl group is readily cleaved by alkaline hydrolysis. For acylation followed by reduction as a route to 3-alkylpyrroles, see: J. Org. Chem., 64, 3379 (1999). See also 1-(Triisopropylsilyl)pyrrole, L13152.
• With a Grignard reagent, e.g. i-PrMgCl, transmetallation occurs at the 2-position, allowing access to 2-substituted derivatives by reaction with electrophiles: Org. Lett., 6, 293 (2004).