Substance
ID:714903
Names and Identifiers
IUPAC Traditional name
trifluoroacetophenone
IUPAC name
2,2,2-trifluoro-1-phenylethan-1-one
Synonyms
Phenyl trifluoromethyl ketone2,2,2-Trifluoroacetophenone2,2,2-三氟苯乙酮Trifluoroacetylbenzene
Registration numbers
EC Number
MDL Number
Beilstein Number
CAS Number
Properties
Physical Property
Melting Point
-40°C
Refractive Index
1.4595
Flash Point
42°C(108°F)
Boiling Point
165-166°C
Density
1.240
Safety Information
GHS Pictograms
Flammable gases, category 1
Flammable aerosols, categories 1,2
Flammable liquids, categories 1,2,3
Self-reactive substances and mixtures, Types B,C,D,E,F
Pyrophoric liquids, category 1
Pyrophoric solids, category 1
Self-heating substances and mixtures
Substances and mixtures, which in contact with water, emit flammable gases, categories 1,2,3
Organic peroxides, Types B,C,D,E,F
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
European Hazard Symbols
Irritant (Xi)UN Number
UN1224
GHS Precautionary statements
P210-P241-P303+P361+P353-P305+P351+P338-P405-P501A
Hazard Class
3
GHS Hazard statements
H226-H315-H319-H335
Risk Statements
10-36/37/38
Safety Statements
26-37
TSCA Listed
是
Packing Group
III
Product Information
Purity
98%
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Olefination with methanesulfonyl chloride, promoted by KF in DMF, gives ɑ -(trifluoromethyl)styrene in 92% yield: J. Org. Chem., 59, 2898 (1994).
• In the presence of KO-t-Bu, acts as a nucleophilic trifluoromethylating agent, converting carbonyl compounds to trifluoromethyl alcohols: Tetrahedron Lett., 44, 1055 (2003).
• Reaction with Dimethyl acetylenedicarboxylate, A11437, in the presence of triphenylphosphine, gives a highly-functionalized -butyrolactone: J. Org. Chem., 61, 4516 (1996):
• Trifluoromethyl ketones undergo selective C-F bond cleavage with Mg in the presence of TMSCl, providing a convenient synthesis of 2,2-difluoro enol silanes: Chem. Commun., 1323 (1999).
• In the presence of potassium monopersulfate (Oxone ), catalyzes the epoxidation of allylic alcohols via the in situ formed dioxirane: Tetrahedron, 56, 989 (1999).