Substance
ID:714578
Names and Identifiers
IUPAC Traditional name
dimethylacetamide
IUPAC name
N,N-dimethylacetamide
Synonyms
N,N-DimethylacetamideN,N-二甲基乙酰胺DMA
Registration numbers
CAS Number
EC Number
Beilstein Number
MDL Number
Merck Index
Properties
Physical Property
Flash Point
70°C(158°F)
Refractive Index
1.4385
Density
0.940
Melting Point
-20°C
Boiling Point
165-166°C
Safety Information
RTECS
AB7700000
Risk Statements
61-20/21
Safety Statements
53-45
European Hazard Symbols
Toxic (T)TSCA Listed
是
GHS Pictograms
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
GHS Precautionary statements
P210-P261-P280-P302+P352-P405-P501A
GHS Hazard statements
H360-H312-H332-H227
Product Information
Purity
99%
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Reacts with alkyl and aryl Grignard reagents to give methyl ketones in good yields: Synthesis, 228 (1984).
• See also Sodium hydride, 13431, for warning.
• Useful solvent in halex fluorinations of chloroarenes; compare Sulfolane, A13466.
• Dipolar aprotic solvent, cf N,N-Dimethylformamide, A13547, Dimethyl sulfoxide, A13280, 1-Methyl-2-pyrrolidinone, A12260.
• Undergoes Vilsmeier-type reactions (compare DMF), with reactive substrates, introducing an acetyl group: Chem. Ber., 97, 616 (1964).
• In the presence of triflic anhydride and 2,4,6-collidine, forms a highly-reactive keteniminium triflate, which undergoes a [2+2] cycloaddition reaction with terminal alkenes to give, after hydrolysis a 3-alkylcyclobutanone: J. Am. Chem. Soc., 107, 2192 (1985); Org. Synth. Coll., 8, 306 (1993):
