Substance
ID:714380
Names and Identifiers
IUPAC Traditional name
1-bromo-2-fluorobenzene
IUPAC name
1-bromo-2-fluorobenzene
Synonyms
1-溴-2-氟苯1-Bromo-2-fluorobenzene2-Bromofluorobenzene
Registration numbers
MDL Number
EC Number
Beilstein Number
CAS Number
Properties
Safety Information
GHS Hazard statements
H226-H302-H319
RTECS
DA1050000
Risk Statements
10-22-36
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Flammable gases, category 1
Flammable aerosols, categories 1,2
Flammable liquids, categories 1,2,3
Self-reactive substances and mixtures, Types B,C,D,E,F
Pyrophoric liquids, category 1
Pyrophoric solids, category 1
Self-heating substances and mixtures
Substances and mixtures, which in contact with water, emit flammable gases, categories 1,2,3
Organic peroxides, Types B,C,D,E,F
European Hazard Symbols
Harmful (X)Safety Statements
26-36
TSCA Listed
是
UN Number
UN1993
GHS Precautionary statements
P280F-P305+P351+P338
Packing Group
III
Hazard Class
3
Physical Property
Flash Point
43°C(109°F)
Density
1.601
Melting Point
-8°C
Refractive Index
1.5340
Boiling Point
155-157°C
Product Information
Purity
99%
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• On treatment with Mg: J. Org. Chem., 49, 4518 (1984), or n-BuLi: Tetrahedron, 48, 4379 (1992), benzyne is generated, which undergoes [4+2] cycloadditions with furans or pyrroles.
• Whereas n-BuLi effects bromine-metal exchange, lithiation with LDA at -75o results in deprotonation ortho to F; subsequent reaction with electrophiles provides access to mixed dihalo derivatives such as 3-bromo-2-fluorobenzoic acid: Tetrahedron Lett., 36, 881 (1995). Improved yields are obtained by the use of lithium 2,2,6,6-tetramethylpiperidide (LTMP) as base: Tetrahedron Lett., 37, 6551 (1996).