Substance
ID:714104
Names and Identifiers
IUPAC name
2-(chloromethyl)pyridine hydrochloride
Synonyms
2-Picolyl chloride hydrochloride2-(Chloromethyl)pyridine hydrochloride2-(氯甲基)吡啶盐酸盐
IUPAC Traditional name
2-(chloromethyl)pyridine hydrochloride
Registration numbers
CAS Number
MDL Number
Beilstein Number
EC Number
Properties
Safety Information
GHS Pictograms
Corrosive to metals, category 1
Skin corrosion, categories 1A,1B,1C
Serious eye damage, category 1
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
European Hazard Symbols
Harmful (X)
Corrosive (C)Storage Warning
Hygroscopic
Safety Statements
24-26-36/37/39-45
TSCA Listed
否
GHS Hazard statements
H301-H311-H317-H314-H318
Packing Group
III
GHS Precautionary statements
P260-P301+P310-P303+P361+P353-P305+P351+P338-P361-P405-P501A
Risk Statements
21/22-34-43
RTECS
US6825000
Hazard Class
8
UN Number
UN3261
Physical Property
Melting Point
120-124°C
Product Information
Purity
98%
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• For a study of the base-catalyzed alkylation of p-t-butylcalix[5]arene, see: J. Org. Chem., 61, 2407 (1996).
• The free base, generated from the hydrochloride with aqueous OH-, can be metallated (LDA, -78o) at the methylene group. Subsequent reaction with a ketone provides a route to otherwise inaccessible pyridyloxiranes: Tetrahedron Lett., 35, 3175 (1994). Similarly, reaction of the lithio derivative with an imine gives a pyridylaziridine, generally in good yield: J. Org. Chem., 60, 2279 (1995).
• The free base has also been used for the protection of OH groups as 2-picolyl derivatives, relatively stable to acid (HF, TFA) but selectively cleaved by electrolytic reduction: Acta Chem. Scand. B, B37, 475 (1983); J. Chem. Res. (Synop.), 22 (1977).