Substance
ID:714067
Names and Identifiers
IUPAC name
trifluoromethanesulfonic acid
Synonyms
Triflic acidTrifluoromethanesulfonic acid三氟甲烷磺酸
IUPAC Traditional name
trifluoromethanesulfonic acid
Registration numbers
CAS Number
MDL Number
EC Number
Beilstein Number
Merck Index
Properties
Safety Information
GHS Pictograms
Corrosive to metals, category 1
Skin corrosion, categories 1A,1B,1C
Serious eye damage, category 1
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
RTECS
PB2771000
GHS Precautionary statements
P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501A
TSCA Listed
是
UN Number
UN3265
Safety Statements
26-36/37/39-45
Storage Warning
Hygroscopic
GHS Hazard statements
H331-H302-H314-H318
Risk Statements
20/22-35
Hazard Class
8
European Hazard Symbols
Harmful (X)
Corrosive (C)Packing Group
II
Physical Property
Density
1.708
Flash Point
None
Refractive Index
1.3270
Boiling Point
161-162°C
Melting Point
-40°C
Product Information
Purity
98+%
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Simple triflic esters, readily prepared by reaction with alcohols, are powerful alkylating agents and must be handled with extreme care because of their irritating effect on the lungs. For a review, see: Synthesis, 85 (1982).
• One of the strongest available monoprotic acids. For a review of the chemistry of triflic acid and its derivatives, see: Chem. Rev., 77, 69 (1977).
• For use in direct electrophilic amination of arenes, see Trimethylsilyl azide, L00173. Effects direct oxy-functionalization of aromatics in combination with bis(TMS) peroxide: J. Org. Chem., 54, 1204 (1989); or sodium perborate: Synlett, 39 (1991).
• Adds to both internal and terminal alkynes to give vinyl triflates: J. Am. Chem. Soc., 91, 4600 (1969); Org. Synth. Coll., 9, 472 (1998). Reaction in the presence of a nitrile provides a route to sterically hindered 2,4,6-trisubstituted pyrimidines: Synthesis, 881 (1990):
