Substance
ID:713728
Names and Identifiers
IUPAC Traditional name
sodium azide
Synonyms
Sodium azide叠氮化钠
IUPAC name
sodium 2λ5-triaz-1-en-2-yn-1-ide
Properties
Physical Property
Melting Point
ca 275°C dec
Solubility
Soluble in water and liquid ammonia. Slightly soluble in alcohol
Apperance
Powder or Granular
Density
1.846
Safety Information
GHS Pictograms
Hazardous to the aquatic environment
Acute hazard, category1
Chronic hazard, categories 1,2
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
GHS Precautionary statements
P273-P264-P301+P310-P321-P405-P501A
European Hazard Symbols
Nature polluting (N)
Highly toxic (T+)GHS Hazard statements
H300-H400-H410
Storage Warning
Air Sensitive
RTECS
VY8050000
TSCA Listed
是
Hazard Class
6.1
UN Number
UN1687
Risk Statements
28-32-50/53
Safety Statements
28-45-60-61
Packing Group
II
Product Information
Purity
99%
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• The reaction of alkyl halides with the highly-nucleophilic azide anion gives alkyl azides which, because of their facile reduction by hydrogenation, SnCl2, P(III) reagents, etc., provide an excellent, mild route to primary amines. For a review of the preparation and synthetic uses of azides, see: Chem. Rev., 88, 297 (1988). The preparation of alkyl azides is ideally suited to phase-transfer methods: Synthesis, 823 (1979); Tetrahedron Lett., 3107 (1978); 30, 1245 (1989). The use of ultrasound has also been found to be effective: Acta Chem. Scand. B, 38, 895 (1984). For a one-pot conversion of alkyl bromides to amines using the Staudinger reaction, see Triethyl phosphite, L00339; see also Triphenylphosphine, L02502. For reviews, see: Tetrahedron, 37, 437 (1981); 48, 1353 (1992).
• Reaction with acyl halides or mixed anhydrides gives acyl azides. These undergo the Curtius rearrangement to isocyanates, which can be isolated, or hydrolyzed in situ to the primary amine. For examples, see: Org. Synth. Coll., 6, 95, 910 (1988).
• For a brief feature on uses of this reagent in Organic synthesis, see: Synlett, 505 (2007).
• Reagent for selective cleavage of methyldiphenylsilyl ethers; see Diphenylmethylchlorosilane, L04162.