Substance
ID:712
Names and Identifiers
Synonyms
TrifluoperazineTrifluoperazine HydrochlorideTrifluoroperazineTryptazine DihydrochlorideTrifluoperazinTriphthazine DihydrochlorideTrifluroperizineTrifluoroperazine DihydrochlorideTrifluoroperazine HydrochlorideTrifluoromethylperazineTrifluoperazine DihydrochlorideTrifluoperazine HClTrifluoperazinaTrifluperazine
IUPAC Traditional name
trifluoperazine
IUPAC name
10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine
Brand Name
ModalinaNovo-TrifluzineTerfluzineTrazineTriftazinTriphtazinEskazinylStelazineStellazineTriphtazineEskazineSynklorTriftazineTriperazineTryptazineFluoperazineJatroneuralTriflurinTriphthasineTriphthazine
Properties
Physical Property
Hydrophobicity(logP)
4.9
Solubility
0.0122 mg/mL at 24 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]
Molecule Details
Drug Groups
approved
Description
A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. [PubChem]
Indication
For the treatment of anxiety disorders, depressive symptoms secondary to anxiety and agitation.
Pharmacology
Trifluoperazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Trifluoperazine has not been shown effective in the management of behaviorial complications in patients with mental retardation.
Toxicity
Symptoms of overdose include agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, and restlessness.
Affected Organisms
Humans and other mammals
Biotransformation
Hepatic.
Half Life
10-20 hours
External Links
Molecular Spectra
No Data Available
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References
No Data Available
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