Substance

ID:698

Names and Identifiers
Synonyms
ROSRosoxacine [INN-French]RosoxacinRosoxacino [INN-Spanish]Acrosoxacin
Brand Name
EradacilEradacinRoxadylEracineWinuron
IUPAC name
1-ethyl-4-oxo-7-(pyridin-4-yl)-1,4-dihydroquinoline-3-carboxylic acid
IUPAC Traditional name
rosoxacin
Registration numbers
PubChem CID
PubChem SID
CAS Number
Properties
Physical Property
Hydrophobicity(logP)
3
Solubility
0.0209 mg/mL at 25 oC [MEYLAN,WM et al. (1996)]
Molecule Details
Drug Groups
approved
Description
Rosoxacin is a quinolone derivative antibiotic for the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients. Rosoxacin is known to be effective against penicillin resistant strains and is a single dose orally administered drug, which avoids all complications of parenteral administration seen with penicillin, especially anaphylactic shock.
Indication
For the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients.
Pharmacology
Rosoxacin is a nonfluorinated quinolone antibiotic. Its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Rosoxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
Affected Organisms
Enteric bacteria and other eubacteria
Molecular Spectra
No Data Available
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References
No Data Available
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