Substance

ID:678

Names and Identifiers
IUPAC Traditional name
tolazoline
IUPAC name
2-benzyl-4,5-dihydro-1H-imidazole
Brand Name
PriscolineImidalinPeripherinePhenylmethylimidazolineVasimidTolazolinVasodilBenzazolineBenzolinBenzylimidazolineDivascolDilatol AsiKasimidLambrilOlitensolPriscolArtonilBenzidazolImidalinePrefaxilVasodilatan
Synonyms
Tolazoline
Registration numbers
CAS Number
PubChem CID
PubChem SID
Properties
Physical Property
Hydrophobicity(logP)
1.5
Solubility
373 mg/L
Molecule Details
Drug Groups
approved
Description
A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn. [PubChem]
Indication
For the treatment of pulmonary artery anomalies
Pharmacology
Tolazoline is a pulmonary vasodilator indicated used to decrease pulmonary vascular resistance (PVR) in persistent pulmonary hypertension of the newborn (PPHN).
Affected Organisms
Humans and other mammals
External Links
Molecular Spectra
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References
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