Substance
ID:676
Names and Identifiers
Brand Name
W-T Sasp OralAzopyrinAzulfidine EN-TabsPMS-SulfasalazinePms-Sulfasalazine E.C.ReupirinSulcolonSalazopyrinSalicylazosulfapyridineSalisulfSalazosulfapyridineBenzosulfaSalazopyrin EN-TabsSalazosulfapyridinColo-PleonS.A.S. Enteric-500SalazopyridinAsulfidineAzopyrineAzulfidineRorasulSalazopiridazinAzlufidine EN-TabsAccucolAlti-Sulfasalazine
Synonyms
SulfasalazineSulfasalazinSulphasalazine
IUPAC name
2-hydroxy-5-[(E)-2-{4-[(pyridin-2-yl)sulfamoyl]phenyl}diazen-1-yl]benzoic acid
IUPAC Traditional name
sulfasalazine
Properties
Physical Property
Hydrophobicity(logP)
2.5
Molecule Details
Drug Groups
approved
Description
A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see mesalamine) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
Indication
For the treatment of Crohn's disease and rheumatoid arthritis as a second-line agent.
Pharmacology
Sulfasalazine is an anti-inflammatory indicated for the treatment of ulcerative colitis and rheumatoid arthritis.
Affected Organisms
Humans and other mammals
Half Life
5-10 hours
Elimination
The majority of 5-ASA stays within the colonic lumen and is excreted as 5-ASA and acetyl-5-ASA with the feces.
Distribution
* 7.5 ± 1.6 L
Clearance
* 1 L/h [IV administration]
External Links
Molecular Spectra
No Data Available
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References
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