Substance

ID:674

Names and Identifiers
Brand Name
AloprogenHaloprogin [USAN:INN:JAN]Haloprogina [INN-Spanish]Haloprogine [INN-French]Haloproginum [INN-Latin]MycandenMycilanHalotexPolik
IUPAC Traditional name
haloprogin
IUPAC name
1,2,4-trichloro-5-[(3-iodoprop-2-yn-1-yl)oxy]benzene
Synonyms
Haloprogin
Registration numbers
CAS Number
777-11-7
PubChem SID
46504892
PubChem CID
3561
Properties
Physical Property
Hydrophobicity(logP)
5.3
Molecule Details
Drug Groups
approved
Description
Haloprogin is used as a topical ointment or cream in the treatment of Tinea infections. Tinea infections are superficial fungal infections caused by three species of fungi collectively known as dermatophytes (Trichophyton, Microsporum and Epidermophyton). Commonly these infections are named for the body part affected, including tinea corporis (general skin), tinea cruris (groin), and tinea pedis (feet). Haloprogin is a halogenated phenolic ether administered topically for dermotaphytic infections. The mechanism of action is unknown, but it is thought to be via inhibition of oxygen uptake and disruption of yeast membrane structure and function.
Indication
Used to treat fungal (Tinea) skin infections such as athlete's foot, jock itch, ringworm, and tinea versicolor.
Pharmacology
Used as a topical ointment or cream in the treatment of Tinea infections. Tinea infections are superficial fungal infections caused by three species of fungi collectively known as dermatophytes (Trichophyton, Microsporum and Epidermophyton). Commonly these infections are named for the body part affected, including tinea corporis (general skin), tinea cruris (groin), and tinea pedis (feet).
Affected Organisms
Dermatophytic fungi including Trichophyton, Microsporum and Epidermophyton
References
• Harrison EF, Zwadyk P Jr, Bequette RJ, Hamlow EE, Tavormina PA, Zygmunt WA: Haloprogin: a topical antifungal agent. Appl Microbiol. 1970 May;19(5):746-50. [Pubmed]
• Harrison EF, Zygmunt WA: Haloprogin: mode of action studies in Candida albicans. Can J Microbiol. 1974 Sep;20(9):1241-5. [Pubmed]
External Links
• [Wikipedia]
• [Drugs.com]
Molecular Spectra
No Data Available
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References
• Harrison EF, Zwadyk P Jr, Bequette RJ, Hamlow EE, Tavormina PA, Zygmunt WA: Haloprogin: a topical antifungal agent. Appl Microbiol. 1970 May;19(5):746-50. Pubmed
• Harrison EF, Zygmunt WA: Haloprogin: mode of action studies in Candida albicans. Can J Microbiol. 1974 Sep;20(9):1241-5. Pubmed
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