Substance
ID:672
Names and Identifiers
Brand Name
Aminouracil MustardUracillostUramustineDesmethyldopanHaemanthamineUracilmostazaChlorethaminacilNordopanUracil nitrogen mustardUramustinDemethyldopan
IUPAC name
5-[bis(2-chloroethyl)amino]-1,2,3,4-tetrahydropyrimidine-2,4-dione
IUPAC Traditional name
uracil mustard
Synonyms
Uracil mustard
Properties
Physical Property
Solubility
1070 mg/L
Hydrophobicity(logP)
1.2
Molecule Details
Drug Groups
approved
Description
Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. [PubChem]
Indication
Used for its antineoplastic properties.
Pharmacology
Uracil Mustard selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Uracil Mustard-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Affected Organisms
Humans and other mammals
Protein Binding
5%
External Links
Molecular Spectra
No Data Available
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References
No Data Available
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