Substance
ID:599
Names and Identifiers
IUPAC Traditional name
norethindrone
Brand Name
AnovuleBrevinor 21Brevinor 28BreviconBinovumBrevinorTriellaUtovlanUtovlarNormapauseNorpregneninotoneOrtho 7 7 7Ortho-Novum 7 7 7Ovysmen 1 35ProluteasiNoraethisteronumNoralutinNorceptNorethisterone [Progestins]Noretisterone [Dcit]NorinylMinovlarNETNeconNelovaNodiolNor-QdCiclovulanConceplanConludafEthynylmortestosteroneEthynylnortestosteroneMilliOvysmen 0.5 35PerovexPrimolut-NSynphasic 28CamilaNoriminNorlutateNorpregneninloneNorpregneninoloneOrtho-NovumOrtho-Novum 1 35Norethin 1/35 ENorethindrone NorethisteroneNorethisteronNorethynodroneNoretisterona [INN-Spanish]Noriday 28GenoraMicronettMicronovumMini-PillModiconNorcept-ETri-NorinylTrinovumLoestrin 24 FeBrevinor-1 21Brevinor-1 28NorlestrinNorlutenNorlutonOrlestOrtho-Novum 1 50OvconNorethin 1/50 MNorethindrone AcetateNorethisteronum [INN-Latin]NorethyndronNorethynodronNorforGestestJenestJenest-28LoestrinNoresthisteroneNorethinAnhydrohydroxynorprogesteroneAnovulatorioAygestinDemulenErrinOrtho 1 35OvysmenPalonylPrimolut NSynphaseTrinovum 21NorcolutNorethadroneNorethisteroneNorgestinNoridayNorlutinMicronethMicronorMini-PeN.E.E.NeoconNor-Q.D.ConludagENTEstrinorEthinylnortestosteroneGenceptMenzol
Synonyms
Norethindrone
IUPAC name
(1S,2R,10R,11S,14R,15S)-14-ethynyl-14-hydroxy-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
Properties
Physical Property
Hydrophobicity(logP)
3.2
Solubility
7.04 mg/L
Molecule Details
Drug Groups
approved
Description
A synthetic progestational hormone with actions similar to those of progesterone but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception. [PubChem]
Indication
For use as an oral contraceptive in the prevention of pregnancy.
Pharmacology
Norethindrone is a synthetic oral progestin. It is used for contraception or to treat such conditions as secondary amenorrhea, abnormal uterine bleeding, and endometriosis. As an oral contraceptive, norethindrone is available as either a single agent or in combination with an estrogen.
Affected Organisms
Humans and other mammals
Biotransformation
Hepatic
Absorption
Absolute oral bioavailability approximately 64%
Half Life
7 hours
Protein Binding
>95%
External Links
Molecular Spectra
No Data Available
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References
No Data Available
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