Substance
ID:582
Names and Identifiers
Brand Name
Nimergoline BaseMNENicergolinum [INN-Latin]VasospanNicotergolineSermionNicergoline [Usan:Ban:Inn:Jan]NimergolineNargolineNicergolin [German]Nicergolina [Dcit]
Synonyms
Nicergoline
IUPAC Traditional name
nicergoline
IUPAC name
[(2S,4R,7R)-2-methoxy-6,11-dimethyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),9,12,14-tetraen-4-yl]methyl 5-bromopyridine-3-carboxylate
Properties
Physical Property
Hydrophobicity(logP)
3.3
Molecule Details
Drug Groups
approved
Description
An ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It has been suggested to ameliorate cognitive deficits in cerebrovascular disease. [PubChem]
Indication
For the treatment of senile dementia, migraines of vascular origin, transient ischemia, platelet hyper-aggregability, and macular degeneration.
Pharmacology
Nicergoline is a potent vasodilator (improves brain blood flow). On the cerebral level it prompts a lowering of vascular resistance, an increase in arterial flow and stimulates the use of oxygen and glucose. Nicergoline also improves blood circulation in the lungs and limbs and has been shown to inhibit blood platelet aggregation.
Affected Organisms
Humans and other mammals
References
•
Winblad B, Fioravanti M, Dolezal T, Logina I, Milanov IG, Popescu DC, Solomon A: Therapeutic use of nicergoline. Clin Drug Investig. 2008;28(9):533-52.
[Pubmed]
External Links
Molecular Spectra
No Data Available
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References
• Winblad B, Fioravanti M, Dolezal T, Logina I, Milanov IG, Popescu DC, Solomon A: Therapeutic use of nicergoline. Clin Drug Investig. 2008;28(9):533-52. Pubmed