Substance
ID:578
Names and Identifiers
IUPAC Traditional name
furosemide
IUPAC name
4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid
Synonyms
FurosemideMetflorylthiazidineFurosemida [INN-Spanish]FursemidFrusemidMethforylthiazidineFrusemideDihydroflumethiazideFurosemidFurosemidu [Polish]Furosemidum [INN-Latin]FursemidaFursemide
Brand Name
AquaridAquasinBristurinCetasixDesalDi-AdemilUritolUrosemideVesixYidoliSalixSalurexSegurilSpirofurUresixUrianMacasiroolNelsixPromidePuresisRadisemideSalinexFuroterFuroviteFursolKutrixLasemidLasilixFuranturilFurixFurosemixTransitTrofuritUremideUrexUridonPromedesProtargenRadonnaRusydeSelectofurSynephronLogireneMyrosemideNadisNeo-RenalOdemasePrefeminHydro-RapidHydroledImpuganLasix RetardLazixLisideFuroreseFurosanFurosideFusidHydrenoxHydroZafimidaFuro-BasanFuromide M.D.Polysquall AProfeminRadounaRodiuranRosemideSaluridLowpstronLuscekMarsemideMirfatNovosemideOctan DraselnyKolkinLasexLasilettenLaxurLess DiurLowpstonFurosixGolanHissufluxHydolHydrexJenafusidFurosifarSal DiureticumSaluronSigasalurSisurilUrex-MVergonilOdemexOedemexOlmagranRetepRontylRosisFrusidFulsixLasix SpecialLeodrineMitaMoilarorinEdenolElodrineFluidrolFranylFrusedanFruseminDesdeminDiucardinDiurapidDiurinDiusemideEdemidLasixAldalixAldicAluzineBeronaldDepixFuro-PurenFurocotFuromenFurosedonKatlexKofuzonFlussFrumideFrumilFrusenexFureticFurmidBristabDirineDiuzolDranexDryptalErrolonFuranthrylFuresisFurfanAnfuramaideApo-FurosemideBioreticFurodiurolFurodrixFuromexFuroseFuluvamideFuranthrilFarsixFruseticFuluvamineFurantrilFurexFurobetaDiurolasaDurafuridEliurFrumexEutensinFrusemaDisemideDiuretic SaltDiusilEnduralDiuralFinuretDisalDiscoidDiumide-KAisemideApo-FrusemideArasemide
Properties
Physical Property
Hydrophobicity(logP)
1.4
Solubility
0.006 mg/mL
Molecule Details
Drug Groups
approved
Description
A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for edema and chronic renal insufficiency. [PubChem]
Indication
For the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Also for the treatment of hypertension alone or in combination with other antihypertensive agents.
Pharmacology
Furosemide, a sulfonamide-type loop diuretic structurally related to bumetanide, is used to manage hypertension and edema associated with congestive heart failure, cirrhosis, and renal disease, including the nephrotic syndrome.
Toxicity
Profound diuresis may cause fluid and electrolyte depletion. Excessive dehydration and potassium depletion may occur. Excessive diuresis may cause rapid weight loss, orthostatic hypotension or acute hypotensive episodes. May also cause tinnitus, reversible or permanent hearing loss or reversible deafness.
Affected Organisms
Humans and other mammals
Biotransformation
Only a small amount is hepatically metabolized to the defurfurylated derivative, 4-chloro-5-sulfamoylanthranilic acid.
Absorption
60% absorbed in patients with normal renal function
Half Life
2 hours
Protein Binding
95% bound to plasma proteins
Elimination
Furosemide is excreted in urine. Significantly more furosemide is excreted in urine following the I.V. injection than after the tablet or oral solution.
References
•
Rais-Bahrami K, Majd M, Veszelovszky E, Short BL: Use of furosemide and hearing loss in neonatal intensive care survivors. Am J Perinatol. 2004 Aug;21(6):329-32.
[Pubmed]
•
Korpi ER, Kuner T, Seeburg PH, Luddens H: Selective antagonist for the cerebellar granule cell-specific gamma-aminobutyric acid type A receptor. Mol Pharmacol. 1995 Feb;47(2):283-9.
[Pubmed]
•
Tia S, Wang JF, Kotchabhakdi N, Vicini S: Developmental changes of inhibitory synaptic currents in cerebellar granule neurons: role of GABA(A) receptor alpha 6 subunit. J Neurosci. 1996 Jun 1;16(11):3630-40.
[Pubmed]
•
Wafford KA, Thompson SA, Thomas D, Sikela J, Wilcox AS, Whiting PJ: Functional characterization of human gamma-aminobutyric acidA receptors containing the alpha 4 subunit. Mol Pharmacol. 1996 Sep;50(3):670-8.
[Pubmed]
External Links
Molecular Spectra
No Data Available
Click here to submit data
References
• Rais-Bahrami K, Majd M, Veszelovszky E, Short BL: Use of furosemide and hearing loss in neonatal intensive care survivors. Am J Perinatol. 2004 Aug;21(6):329-32. Pubmed
• Tia S, Wang JF, Kotchabhakdi N, Vicini S: Developmental changes of inhibitory synaptic currents in cerebellar granule neurons: role of GABA(A) receptor alpha 6 subunit. J Neurosci. 1996 Jun 1;16(11):3630-40. Pubmed
• Korpi ER, Kuner T, Seeburg PH, Luddens H: Selective antagonist for the cerebellar granule cell-specific gamma-aminobutyric acid type A receptor. Mol Pharmacol. 1995 Feb;47(2):283-9. Pubmed
• Wafford KA, Thompson SA, Thomas D, Sikela J, Wilcox AS, Whiting PJ: Functional characterization of human gamma-aminobutyric acidA receptors containing the alpha 4 subunit. Mol Pharmacol. 1996 Sep;50(3):670-8. Pubmed