Substance
ID:559
Names and Identifiers
IUPAC Traditional name
benzyl benzoate
IUPAC name
benzyl benzoate
Brand Name
Benzoic acid benzyl esterBenzyl benzenecarboxylateBenzyl esterBenzyl phenylformatePeruscabinScabitoxScabagenScabideScabiozonScobenolVenzonateBenzylester kyseliny benzooveBenzyletsNovoscabinBenzyl alcohol benzoic esterBenzyl benzoate 99+ %ColebenzScabancaVenzoateBenzoic acid, benzyl esterVanzoateAscabinAscabiolBenylateBenzoic acid, phenylmethyl ester
Synonyms
Benzyl Benzoate
Properties
Physical Property
Solubility
15.4 mg/L
Hydrophobicity(logP)
3.7
Molecule Details
Drug Groups
approved
Description
Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties.
Indication
Used to kill lice and the mites responsible for the skin condition scabies.
Pharmacology
Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties.
Toxicity
Oral, rabbit: LD50 = 1680 mg/kg; Skin, rabbit: LD50 = 4000 mg/kg. Symptoms of overdose include blister formation, crusting, itching, oozing, reddening, or scaling of skin; difficulty in urinating (dribbling); jerking movements; sudden loss of consciousness.
Affected Organisms
Sarcoptes scabiei
Biotransformation
Rapidly hydrolyzed to benzoic acid and benzyl alcohol, which is further oxidized to benzoic acid. The benzoic acid is conjugated with glycine to form hippuric acid.
Absorption
No data are available on percutaneous absorption of benzyl benzoate. Some older studies have suggested some percutaneous absorption, however the amount was not quantified.
References
•
Bachewar NP, Thawani VR, Mali SN, Gharpure KJ, Shingade VP, Dakhale GN: Comparison of safety, efficacy, and cost effectiveness of benzyl benzoate, permethrin, and ivermectin in patients of scabies. Indian J Pharmacol. 2009 Feb;41(1):9-14.
[Pubmed]
•
Buffet M, Dupin N: Current treatments for scabies. Fundam Clin Pharmacol. 2003 Apr;17(2):217-25.
[Pubmed]
External Links
Molecular Spectra
No Data Available
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References
• Buffet M, Dupin N: Current treatments for scabies. Fundam Clin Pharmacol. 2003 Apr;17(2):217-25. Pubmed
• Bachewar NP, Thawani VR, Mali SN, Gharpure KJ, Shingade VP, Dakhale GN: Comparison of safety, efficacy, and cost effectiveness of benzyl benzoate, permethrin, and ivermectin in patients of scabies. Indian J Pharmacol. 2009 Feb;41(1):9-14. Pubmed