Substance
ID:522
Names and Identifiers
Synonyms
Butoconazolum [INN-Latin]Butoconazol [INN-Spanish]ButoconazoleButoconazole nitrate
IUPAC name
1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)sulfanyl]butyl]-1H-imidazole
Brand Name
Femstat 3Gynazole-1Femstat
IUPAC Traditional name
butoconazole
Properties
Physical Property
Hydrophobicity(logP)
6.7
Solubility
Nitrate salt: 0.26 mg/ml (practically insoluble)
Molecule Details
Drug Groups
approved
Description
Butoconazole is an imidazole antifungal used in gynecology.
Indication
For the local treatment of vulvovaginal candidiasis (infections caused by Candida)
Pharmacology
Butoconazole is an imidazole derivative that has fungicidal activity in vitro against Candida spp. and has been demonstrated to be clinically effective against vaginal infections due to Candida albicans. Candida albicans has been identified as the predominant species responsible for vulvovaginal candidasis.
Toxicity
Oral, rat: LD50 = >1720 mg/kg.
Affected Organisms
Fungi, yeast and protozoans
Absorption
Following vaginal administration of butoconazole nitrate vaginal cream, 2% to 3 women, 1.7% (range 1.3-2.2%) of the dose was absorbed on average.
External Links
Molecular Spectra
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References
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