Substance
ID:504
Names and Identifiers
Synonyms
OxandroloneOxandrolonum [INN-Latin]oxandroloneOssandrolone [DCIT]Oxandrolona [INN-Spanish]
IUPAC Traditional name
oxandrolone
IUPAC name
(1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,14,15-trimethyl-4-oxatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-one
Brand Name
ProvitarLonavarProtivarOxandrinAnavarVasorome
Properties
Physical Property
Hydrophobicity(logP)
4.2
Molecule Details
Drug Groups
approved; investigational
Description
A synthetic hormone with anabolic and androgenic properties. [PubChem]
Indication
Use to promote weight gain after weight loss following extensive surgery.
Pharmacology
Oxandrolone is an anabolic steroids indicated as adjunctive therapy to promote weight gain after weight loss following extensive surgery, chronic infections, or severe trauma, and in some patients who without definite pathophysiologic reasons fail to gain or to maintain normal weight, to offset the protein catabolism associated with prolonged administration of corticosteroids, and for the relief of the bone pain frequently accompanying osteoporosis. Anabolic steroids are synthetic derivatives of testosterone.
Toxicity
The oral LD50 of oxandrolone in mice and dogs is greater than 5,000 mg/kg.
Affected Organisms
Humans and other mammals
Biotransformation
Renal
Half Life
0.55 hours (1st phage), 9 hours (2nd phase)
References
•
Demling RH, DeSanti L: Oxandrolone induced lean mass gain during recovery from severe burns is maintained after discontinuation of the anabolic steroid. Burns. 2003 Dec;29(8):793-7.
[Pubmed]
External Links
Molecular Spectra
No Data Available
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References
• Demling RH, DeSanti L: Oxandrolone induced lean mass gain during recovery from severe burns is maintained after discontinuation of the anabolic steroid. Burns. 2003 Dec;29(8):793-7. Pubmed